Bone is a dynamic tissue in the human body, where many factors are responsible for its homeostasis.

Factors such as:

* Age

* Hormones

* Physical Stimuli (Lack of teeth)

* Nutrition

* Genetics

* Trauma

* Etcetera….

All of those factors, play a critical role against normative homeostasis in our bone tissue and give preference to its dismantlement by osteoclasts, resulting in bone tissue resorption in time.

Bone resorption in the maxilla as in the mandible following partial edentulism or complete edentulism, accompanied by gingival resorption, will result in facial deformities.

 Bone Resorption of Edentulous Male Fascial Deformities

Biological Mechanism of Bone Tissue Degradation:

Researches in this field indicate that mechanical stimuli affect bone metabolism. When there is lack of stimuli, on the cellular level we can observe changes in the fluid flow in the canalicular network of the bone tissue (Lacuna), as well as changes in the intramedullary (Inside the bone tissue) pressure.

 Histological slide of bone resorption – Osteoblast to Osteoclast ratio


Histological slide of bone resorption – Osteoblast to Osteoclast ratio


Health Issues with Lack of Bone Tissue:

Facial deformity due to lack of bone, is presented by less volume in the maxilla and mandible regions, which creates aesthetically inadequate and unattractive facial features, moreover causes speech impairment and proper food intake inability.

Health issues connected to the lack of Bone tissue head beyond the facial area, where it leads to loss of teeth, that result in improper mechanical food digestion in the oral cavity, and in time may lead to a large variety of diseases and conditions in the digestive system, for example:

* Bloating

* Slower Metabolism

* Obesity

lack of tissue around adjacent teeth (of the lost tooth) that leads to plaque build-up and bacteria formation

Another aspect is lack of tissue around adjacent teeth (of the lost tooth) that leads to plaque build-up and bacteria formation causing tooth decay, thus increasing the chances of different types of bacteria to reach the heart and cause Endocarditis (Inflammation of the heart muscle).

Bone Resorption Solutions:

The optimal solution to both restore and prevent bone & gingiva tissue resorption is Guided Bone Regeneration (GBR) and Guided Tissue Regeneration (GTR) procedures, followed by implant placement after a certain healing period.

GBR – Guided Bone Regeneration Procedure:

Aimed to augment or repair any defect to the alveolar ridge, that has shrunk due to described factors, to prepare the tissue for a future or immediate implant loading.

Main and important materials used in GBR procedures are bone graft and resorbable/non-resorbable membranes.

Zenoss Plus Xenograft Biological Properties and Appliances:

DSI – Dental Solutions presents a revolutionary product, aimed to achieve high standards in GBR and post-extraction procedures. Derived from bovine origin, Zenoss+ comes in a pre-filled sterile syringe, dedicated for a simple and practical application to the defect site (single use only).

Zenoss bone graft characterized by pro osseointegration chemical and physical properties, such as osteoconductivity and human bone matrix similarity.

Zenoss Plus Uniqueness and Use:

Zenoss Plus incorporates a reversed thermoplasticity polymer that blends the xenograft granules into a homogenous paste, allowing the temperature to change its physical state depending on the temperature. The material will become completely liquefied at 8°C/46F, and harden at 25°C/77F, allowing the clinician a full control over the viscosity of the product.

Zenoss Plus Conclusion and Instruction:

Zenoss Plus assures immediate stability at the defect after placement without membrane due to a rapid solidification at the intraoral environment.

Perfect for application in the following cases:

* Immediate placement technique.

* Augmentation of Reconstruction of the alveolar ridge (GBR).

* Peri-Implant defects filling.

* Preservation of the alveolar ridge by socket filling (post-extraction)

* Root resection, apicoectomy and cystectomy defects filling.

* Sinus Augmentation.

Zenoss Plus is simple to use as 1-2-3:

1. Granules should be wetted with a saline physiological solution or patient’s blood and then pushed down by the plunger. Repeat until the graft is fully hydrated. The filter cap prevents the bone graft granules from falling. According to the recent studies, to achieve the best results use 90%:10% blood/saline combination.

2. Remove the perforated cap and deliver the hydrated granules into the defect.

3. Apply light pressure with a gauze pad.

And to finish, close the flap or continue with the operation. The pore-interconnected structure of Zenoss Plus granules grants the material an ability, to guide the growth of the bone marrow and cells while allowing the body fluids and blood vessel to pass through.

DSI Zenoss Plus is your trusted product of choice, engineered to deliver you the best results in an easy, fast and most efficient way possible!

GBR bone augmentation dental graft regeneration guide zenoss plus xenograft

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